Answers
To ensure one way communication of impulses.
11 October 2017
To release neurotransmitters and facilitate transmission of signals.
21 October 2017
Synaptic vesicles are small vesicles clustered at presynaptic terminals. Their role is to store and release neurotransmitters, which is triggered by exocytosis. This ensures signals to be transmitted in one direction only.
25 October 2017
Synaptic vesicles
Chemical synapses provide the
predominant form of fast
functional information transfer
between neurons in the brain.
Synaptic transmission is initiated
in a presynaptic neuron when
neurotransmitter-containing
vesicles release their contents into
the synaptic cleft, which physically
separates the presynaptic and
postsynaptic neurons. The
released neurotransmitter
molecules then bind to their
cognate receptors on the
postsynaptic neuron, eliciting an
array of chemical and electrical
changes. Early physiological
studies made profound
contributions to our understanding
of the discrete (quantal) nature of
neurotransmitter release and its
calcium-dependence. Over the
past two decades, our knowledge
of synapse operation has been
advanced by molecular biological,
genetic and biochemical
The presynaptic terminal,
located along the axon of most
neurons, is a compartment where
neurotransmitter-containing
vesicles cluster near a highly
specialized region of the plasma
membrane called the ‘active zone’.
From there, vesicles release their
contents during synaptic
transmission. There are exceptions
to this general architecture — for
example, presynaptic
specializations can occur in
dendrites rather than in axons and
there are synapses specialized for
continuous release that do not
have conventional active zones,
but have ‘ribbons’. Before
neurotransmitter release can occur
from a given release site, synaptic
vesicles must be sorted,
translocated to the active zone,
dock and be primed for fusion.
Synaptic vesicle recycling is an
integral feature of presynaptic
function, therefore, we have
chosen the synaptic vesicle cycle
as the central theme of this Primer.
trafficking and recycling. In fact,
when axons are severed from
their soma, the terminals are
capable of remaining functional
for quite some time. In addition to
synaptic vesicles, the presynaptic
terminal is enriched with
components required for both
exocytosis and endocytosis:
these include specialized
neurotransmitter transporters to
repackage empty vesicles;
endosome organelles that might
mediate some aspects of vesicle
recycling; elements of smooth
endoplasmic reticulum that may
regulate intracellular Ca2+;
mitochondria to meet the energy
demands placed on the vesicle
cycle; and a matrix of cytoskeletal
elements and scaffolding proteins
thought to facilitate synaptic
vesicle sorting. A large number of
cytoplasmic and plasma
membrane proteins that appear to
play regulatory roles are also
found in synapses.The reason is , synaptic vesicles contain neurotransmitters. These neurotransmitters are then released into synaptic clefts and then mediate their action on postsynaptic neurons. Well to understand the concept of how neurotransmitters work, we first need to understand the role of voltage-gated ca channels located in the presynaptic neuron and the mechanisms on how they are exocytosed into the cleft. I will be glad to explain these steps in further detail with the help of some videos and talk about some diseases underlying the concepts of neurotransmitters. I hope this will help you ! Thanku !
12 July 2018
Add an answer
Similar questions