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Competitive inhibition is when the inhibitor blocks the active site of an enzyme, preventing substrates from binding. Think of this as a defender blocking the goal in a football game to prevent the other team from scoring. Non-Competitive inhibition is when the inhibitor changes the shape of the active sight so the substrate can no longer bind to the enzyme. This would be like a team changing the shape of the net so that the ball no longer fits inside the goal and the other team cant score.