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Hey there Stella, This is really a great question and some students find these areas kinda tricky. So to answer this question, we first need to understand the metabolism pathway. To answer your question, the Krebs cycle (glycolysis) plays a vital role in the mitochondria to generate the most ATP (36). I would be willing to explain and draw out the metabolism pathway and explain some important metabolic diseases regarding this pathway. 

Aerobic respiration in the mitochondria, more specifically the Keen cycle. In the glycolysis stage, for each molecule of glucose, 2ATP, 2NADPH and 2pyruvates are made.

Pyruvate from glycolysis enters the kreb cycle where a net of 36ATP molecules are made along with more reduced NADP and FAD. That's a lot of ATPs pet glucose. Remember this value is the theoretical maximum. As this is an enzyme controlled processes, the actual number of ATP produced maybe a lot lower.

I am a qualified biology teacher, do let me know if you are interested in having lessons. 


This is via the Krebs cycle phase of aerobic respiration, which takes place in the mitochondria. In this cycle, there is a net gain of 36 ATP molecules via the oxidation of glucose.

Aerobic respiration (specifically Krebs cycle).

Aerobic respiration

Aerobic respiration

Glucose oxidised by Mitochondria creates 36 net ATP. Conversion of glucose by hexokinases leading to pyruvate and entering mitochondria to join TCA cycle is the most efficient way to utilise glucose.

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